vit-2 Vitellogenin-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vit-2
Official Full Name: Vitellogenin-2
Primary source: WormBase:WBGene00006926
Locus tag: CELE_C42D8.2
See related: AllianceGenome:WB:WBGene00006926
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable lipid transporter activity. Predicted to be involved in lipid transport. Located in cytoplasmic vesicle; vesicle lumen; and yolk granule. Is expressed in embryonic cell; gonad; intestine; oocyte; and pseudocoelom. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vit-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 5

Sequence:: Chromosome: X; NC_003284.9 (5101042..5106169)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the C. elegans 44 bp enhancer from vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-beta/Sma/Mab pathway
Title: A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-β/Sma/Mab pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C42D8.2 (e-PCR)
- UniSTS:308756

K09F5.2 (e-PCR)
- UniSTS:312410

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid transporter activity	IEA Inferred from Electronic Annotation more info
enables nutrient reservoir activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in vesicle lumen	IDA Inferred from Direct Assay more info	PubMed
located_in yolk granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Vitellogenin-2

NP_508868.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

5101042..5106169

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076467.7 → NP_508868.1 Vitellogenin-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508868.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P05690

Conserved Domains (3) summary

smart00216
Location:1299 → 1456

VWD; von Willebrand factor (vWF) type D domain

pfam01347
Location:24 → 618

Vitellogenin_N; Lipoprotein amino terminal region

pfam09172
Location:653 → 944

DUF1943; Domain of unknown function (DUF1943)