air-2 Aurora/IPL1-related protein kinase 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: air-2
Official Full Name: Aurora/IPL1-related protein kinase 2
Primary source: WormBase:WBGene00000099
Locus tag: CELE_B0207.4
See related: AllianceGenome:WB:WBGene00000099
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ATPase binding activity; kinesin binding activity; and protein kinase activity. Involved in several processes, including chromosome condensation; regulation of actomyosin contractile ring contraction; and spindle midzone assembly. Located in condensed nuclear chromosome and spindle midzone. Is expressed in oocyte and sperm. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; spermatogenic failure 5; and uterine cancer. Orthologous to several human genes including AURKB (aurora kinase B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See air-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (5937477..5938876)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A degron-based strategy reveals new insights into Aurora B function in C. elegans.
Title: A degron-based strategy reveals new insights into Aurora B function in C. elegans.
C. elegans CLASP/CLS-2 negatively regulates membrane ingression throughout the oocyte cortex and is required for polar body extrusion.
Title: C. elegans CLASP/CLS-2 negatively regulates membrane ingression throughout the oocyte cortex and is required for polar body extrusion.
we demonstrate that cytokinesis is implemented in a specialized way during epithelial polarization and that Aurora B has a role in the formation of the apical surface
Title: Aurora B functions at the apical surface after specialized cytokinesis during morphogenesis in C. elegans.
Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis.
Title: Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis.
Chromatin obstructions activated Aurora B at the spindle midzone, which is needed for the abscission checkpoint in other systems. Condensin I, but not condensin II, localizes to the spindle midzone in anaphase and to the midbody during normal cytokinesis.
Title: Condensin and the spindle midzone prevent cytokinesis failure induced by chromatin bridges in C. elegans embryos.
LAB-1 directly targets GSP-2 to the chromatin during meiotic onset, thus restricting aberrant AIR-2 accumulation at that stage and promoting normal establishment and maintenance of sister chromatid cohesion.
Title: LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion.
The results suggest that CDC-48s control the restricted localization of AIR-2 to the cohesion sites of homologous chromatids in meiosis I.
Title: CDC-48/p97 is required for proper meiotic chromosome segregation via controlling AIR-2/Aurora B kinase localization in Caenorhabditis elegans.
During both mitosis and meiosis, the localization of condensin I, but not condensin II, parallels the localization of air2.
Title: Different roles for Aurora B in condensin targeting during mitosis and meiosis.
TLK-1 functions in cytokinesis by localizing AIR-2 to the midzone microtubules.
Title: Caenorhabditis elegans TLK-1 controls cytokinesis by localizing AIR-2/Aurora B to midzone microtubules.
An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2.
Title: An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0207.6 (e-PCR)
- UniSTS:313362

B0207.4 (e-PCR)
- UniSTS:308343

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone H3 kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3 kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic spindle midzone assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle midzone assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of actomyosin contractile ring contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of actomyosin contractile ring contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Aurora/IPL1-related protein kinase 2

NP_491714.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5937477..5938876

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059313.9 → NP_491714.1 Aurora/IPL1-related protein kinase 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491714.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01427

Conserved Domains (2) summary

smart00220
Location:30 → 280

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14007
Location:29 → 281

STKc_Aurora; Catalytic domain of the Serine/Threonine kinase, Aurora kinase