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    shk-1 Potassium voltage-gated channel protein shk-1 [ Caenorhabditis elegans ]

    Gene ID: 174536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    shk-1
    Official Full Name
    Potassium voltage-gated channel protein shk-1
    Primary source
    WormBase:WBGene00014261
    Locus tag
    CELE_ZK1321.2
    See related
    AllianceGenome:WB:WBGene00014261
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables delayed rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Is expressed in body wall musculature; head ganglion; interneuron; muscle cell; and sensory neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32; episodic ataxia type 1; familial atrial fibrillation; and pulmonary hypertension. Orthologous to several human genes including KCNA1 (potassium voltage-gated channel subfamily A member 1); KCNA10 (potassium voltage-gated channel subfamily A member 10); and KCNA2 (potassium voltage-gated channel subfamily A member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See shk-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    17
    Sequence:
    Chromosome: II; NC_003280.10 (9758232..9768285)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Putative aquaporin-10 Neighboring gene PDZ domain-containing protein Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans AWA Olfactory Neurons Fire Calcium-Mediated All-or-None Action Potentials. Liu Q, et al. Cell, 2018 Sep 20. PMID 30220455
    2. Genetic dissection of ion currents underlying all-or-none action potentials in C. elegans body-wall muscle cells. Liu P, et al. J Physiol, 2011 Jan 1. PMID 21059759, Free PMC Article
    3. Mutant analysis of the Shal (Kv4) voltage-gated fast transient K+ channel in Caenorhabditis elegans. Fawcett GL, et al. J Biol Chem, 2006 Oct 13. PMID 16899454, Free PMC Article
    4. SLO-2 potassium channel is an important regulator of neurotransmitter release in Caenorhabditis elegans. Liu P, et al. Nat Commun, 2014 Oct 10. PMID 25300429, Free PMC Article
    5. Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans. Honda Y, et al. Sci Rep, 2012. PMID 22768380, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Potassium voltage-gated channel protein shk-1
    NP_001022516.1
    • Partially confirmed by transcript evidence
    NP_001040829.1
    • Confirmed by transcript evidence
    NP_496104.2
    • Confirmed by transcript evidence
    NP_871934.1
    • Confirmed by transcript evidence
    NP_871935.1
    • Partially confirmed by transcript evidence
    NP_871936.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9758232..9768285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_182134.6 → NP_871934.1  Potassium voltage-gated channel protein shk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871934.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I4B0
      Conserved Domains (4) summary
      smart00225
      Location:135 → 226
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:306 → 507
      Ion_trans; Ion transport protein
      pfam02214
      Location:135 → 226
      BTB_2; BTB/POZ domain
      pfam07885
      Location:420 → 492
      Ion_trans_2; Ion channel

    2. NM_063703.5 → NP_496104.2  Potassium voltage-gated channel protein shk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496104.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I4B0
      Conserved Domains (4) summary
      smart00225
      Location:92 → 183
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:263 → 464
      Ion_trans; Ion transport protein
      pfam02214
      Location:92 → 183
      BTB_2; BTB/POZ domain
      pfam07885
      Location:377 → 449
      Ion_trans_2; Ion channel

    3. NM_182135.6 → NP_871935.1  Potassium voltage-gated channel protein shk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871935.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E3W725, Q09658, Q14V33, Q6BEV2, Q8I4A9, Q8I4B0, Q8I4B1
      Conserved Domains (4) summary
      smart00225
      Location:135 → 238
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:318 → 519
      Ion_trans; Ion transport protein
      pfam02214
      Location:135 → 238
      BTB_2; BTB/POZ domain
      pfam07885
      Location:432 → 504
      Ion_trans_2; Ion channel

    4. NM_182136.6 → NP_871936.1  Potassium voltage-gated channel protein shk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871936.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I4B0
      Conserved Domains (4) summary
      smart00225
      Location:100 → 203
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:283 → 484
      Ion_trans; Ion transport protein
      pfam02214
      Location:100 → 203
      BTB_2; BTB/POZ domain
      pfam07885
      Location:397 → 469
      Ion_trans_2; Ion channel

    5. NM_001027345.5 → NP_001022516.1  Potassium voltage-gated channel protein shk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022516.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I4B0
      Conserved Domains (4) summary
      smart00225
      Location:59 → 150
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:230 → 431
      Ion_trans; Ion transport protein
      pfam02214
      Location:59 → 150
      BTB_2; BTB/POZ domain
      pfam07885
      Location:344 → 416
      Ion_trans_2; Ion channel

    6. NM_001047364.4 → NP_001040829.1  Potassium voltage-gated channel protein shk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040829.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I4B0
      Conserved Domains (4) summary
      smart00225
      Location:46 → 137
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:217 → 418
      Ion_trans; Ion transport protein
      pfam02214
      Location:46 → 137
      BTB_2; BTB/POZ domain
      pfam07885
      Location:331 → 403
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I4B0.1

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