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    his-35 Histone H2A [ Caenorhabditis elegans ]

    Gene ID: 179339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    his-35
    Official Full Name
    Histone H2A
    Primary source
    WormBase:WBGene00001909
    Locus tag
    CELE_C50F4.13
    See related
    AllianceGenome:WB:WBGene00001909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of chromatin. Predicted to be involved in heterochromatin formation. Predicted to be located in chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to several human genes including H2AX (H2A.X variant histone). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See his-35 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (9544659..9545288, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Nudix hydrolase domain-containing protein Neighboring gene uncharacterized protein Neighboring gene putative histone H2B 3 Neighboring gene Cold-shock protein Neighboring gene Histone H4 Neighboring gene GDP-fucose transporter;Sugar phosphate transporter domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nematode histone H2A variant evolution reveals diverse histories of retention and loss and evidence for conserved core-like variant histone genes. Singh S, et al. PLoS One, 2024. PMID 38814971, Free PMC Article
    2. The Caenorhabditis elegans histone hairpin-binding protein is required for core histone gene expression and is essential for embryonic and postembryonic cell division. Pettitt J, et al. J Cell Sci, 2002 Feb 15. PMID 11865041
    3. Robust co-immunoprecipitation with mass spectrometry for Caenorhabditis elegans using solid-phase enhanced sample preparation. Baytek G, et al. Biotechniques, 2022 May. PMID 35297663
    4. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nematode histone H2A variant evolution reveals diverse histories of retention and loss and evidence for conserved core-like variant histone genes.
      Title: Nematode histone H2A variant evolution reveals diverse histories of retention and loss and evidence for conserved core-like variant histone genes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Histone H2A
    NP_505463.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9544659..9545288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073062.10 → NP_505463.1  Histone H2A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505463.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q27485
      Conserved Domains (1) summary
      PTZ00017
      Location:18 → 127
      PTZ00017; histone H2A; Provisional
    Nucleotide Protein
    Heading Accession and Version

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