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    hpo-11 Protein kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186807, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hpo-11
    Official Full Name
    Protein kinase domain-containing protein
    Primary source
    WormBase:WBGene00010427
    Locus tag
    CELE_H37N21.1
    See related
    AllianceGenome:WB:WBGene00010427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm and endomembrane system. Is expressed in several structures, including excretory gland cell; intestine; nervous system; reproductive system; and seam cell. Orthologous to human NRBP1 (nuclear receptor binding protein 1) and NRBP2 (nuclear receptor binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hpo-11 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    14
    Sequence:
    Chromosome: I; NC_003279.8 (7138482..7147578, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RUN domain-containing protein Neighboring gene TAFII28-like protein domain-containing protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene ncRNA Neighboring gene FErroChelatase-Like Neighboring gene CARMIL pleckstrin homology domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. De Langhe S, et al. Int J Mol Med, 2002 May. PMID 11956649
    2. A Screen of the Conserved Kinome for Negative Regulators of LIN-12 Negative Regulatory Region ("NRR")-Missense Activity in Caenorhabditis elegans. Deng Y, et al. G3 (Bethesda), 2019 Nov 5. PMID 31519743, Free PMC Article
    3. Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. Wilson CH, et al. EMBO J, 2012 May 30. PMID 22510880, Free PMC Article
    4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein
    NP_492022.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7138482..7147578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059621.5 → NP_492022.3  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492022.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED17
      Conserved Domains (2) summary
      PHA03255
      Location:376 → 490
      PHA03255; BDLF3; Provisional
      cl21453
      Location:50 → 311
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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