ech-6 putative enoyl-CoA hydratase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ech-6
Official Full Name: putative enoyl-CoA hydratase, mitochondrial
Primary source: WormBase:WBGene00001155
Locus tag: CELE_T05G5.6
See related: AllianceGenome:WB:WBGene00001155
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial short-chain enoyl-CoA hydratase 1 deficiency. Orthologous to human ECHS1 (enoyl-CoA hydratase, short chain 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ech-6 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (9751552..9752883, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T05G5.6 (e-PCR)
- UniSTS:310685

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables enoyl-CoA hydratase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative enoyl-CoA hydratase, mitochondrial

NP_001366674.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9751552..9752883 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001379869.3 → NP_001366674.1 putative enoyl-CoA hydratase, mitochondrial [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P34559

Conserved Domains (1) summary

cl23717
Location:32 → 284

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...