gcp-2.1 Glutamate carboxypeptidase 2 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gcp-2.1
Official Full Name: Glutamate carboxypeptidase 2 homolog
Primary source: WormBase:WBGene00020082
Locus tag: CELE_R57.1
See related: AllianceGenome:WB:WBGene00020082
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and cerebral infarction. Orthologous to several human genes including NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2); NAALADL1 (N-acetylated alpha-linked acidic dipeptidase like 1); and FOLH1 (folate hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gcp-2.1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 13

Sequence:: Chromosome: X; NC_003284.9 (301830..308303)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

R57.1 (e-PCR)
- UniSTS:318387

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Glutamate carboxypeptidase 2 homolog

NP_001024866.1

Confirmed by transcript evidence

NP_508085.2

Confirmed by transcript evidence

NP_872248.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

301830..308303

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075684.8 → NP_508085.2 Glutamate carboxypeptidase 2 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508085.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P91406, Q65ZG3, Q65ZG4, Q86FL5

Conserved Domains (4) summary

cd08022
Location:363 → 605

M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen

cd02121
Location:127 → 356

PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...

pfam04253
Location:639 → 767

TFR_dimer; Transferrin receptor-like dimerization domain

cl14876
Location:67 → 137

Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
NM_001029695.7 → NP_001024866.1 Glutamate carboxypeptidase 2 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024866.1

Status: REVIEWED

UniProtKB/TrEMBL

G8JYE4

Conserved Domains (4) summary

cd08022
Location:344 → 586

M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen

cd02121
Location:108 → 337

PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...

pfam04253
Location:627 → 748

TFR_dimer; Transferrin receptor-like dimerization domain

cl14876
Location:48 → 118

Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
NM_182448.5 → NP_872248.2 Glutamate carboxypeptidase 2 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_872248.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P91406

Conserved Domains (3) summary

cd08022
Location:344 → 575

M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen

cd02121
Location:108 → 337

PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...

cl14876
Location:48 → 118

Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42