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    zmp-6 Peptidase metallopeptidase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176025, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zmp-6
    Official Full Name
    Peptidase metallopeptidase domain-containing protein
    Primary source
    WormBase:WBGene00020646
    Locus tag
    CELE_T21D11.1
    See related
    AllianceGenome:WB:WBGene00020646
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to be located in extracellular matrix. Is expressed in anchor cell. Human ortholog(s) of this gene implicated in artery disease (multiple); bone disease (multiple); ovarian carcinoma; and tooth disease (multiple). Orthologous to several human genes including MMP26 (matrix metallopeptidase 26). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See zmp-6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (7245701..7247840, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene proline--tRNA ligase Neighboring gene C2H2-type domain-containing protein Neighboring gene Major sperm protein Neighboring gene Uncharacterized protein Neighboring gene Phosphatidylserine decarboxylase beta chain Neighboring gene Putative methyltransferase B0361.6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs. Kelley LC, et al. Dev Cell, 2019 Feb 11. PMID 30686527, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase metallopeptidase domain-containing protein
    NP_498599.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7245701..7247840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066198.7 → NP_498599.1  Peptidase metallopeptidase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498599.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECC4
      Conserved Domains (1) summary
      cd04278
      Location:48 → 205
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    Nucleotide Protein
    Heading Accession and Version

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