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    crh-2 CREB homolog crh-2 [ Caenorhabditis elegans ]

    Gene ID: 259434, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crh-2
    Official Full Name
    CREB homolog crh-2
    Primary source
    WormBase:WBGene00016162
    Locus tag
    CELE_C27D6.4
    See related
    AllianceGenome:WB:WBGene00016162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cAMP response element binding activity. Involved in defense response to Gram-negative bacterium; positive regulation of dauer entry; and regulation of gene expression. Predicted to be located in nucleus. Is expressed in several structures, including hypodermis; intestine; nervous system; pharynx; and spermatheca. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 16. Orthologous to several human genes including CREB3L1 (cAMP responsive element binding protein 3 like 1) and CREB3L2 (cAMP responsive element binding protein 3 like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See crh-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (5179026..5187569, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Multicopper oxidase;Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major sperm protein 49

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prediction pipeline for discovery of regulatory motifs associated with Brugia malayi molting. Grote A, et al. PLoS Negl Trop Dis, 2020 Jun. PMID 32574217, Free PMC Article
    2. Intergenerational Pathogen-Induced Diapause in Caenorhabditis elegans Is Modulated by mir-243. Gabaldón C, et al. mBio, 2020 Sep 22. PMID 32963007, Free PMC Article
    3. Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development. Oommen KS, et al. Development, 2007 Nov. PMID 17942488
    4. A genome-wide map of conserved microRNA targets in C. elegans. Lall S, et al. Curr Biol, 2006 Mar 7. PMID 16458514
    5. Maternal H3K36 and H3K27 HMTs protect germline development via regulation of the transcription factor LIN-15B. Cockrum CS, et al. Elife, 2022 Aug 3. PMID 35920536, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dauer entry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CREB homolog crh-2
    NP_001293486.1
    • Confirmed by transcript evidence
    NP_740985.2
    • Confirmed by transcript evidence
    NP_740986.2
    • Confirmed by transcript evidence
    NP_740987.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5179026..5187569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170988.7 → NP_740986.2  CREB homolog crh-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740986.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4JFI0
      Conserved Domains (1) summary
      cd14689
      Location:261 → 321
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    2. NM_170989.11 → NP_740987.4  CREB homolog crh-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740987.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09636, Q4JFH9, Q4JFI0, Q95ZX9, S6FD32
      Conserved Domains (1) summary
      cd14689
      Location:283 → 343
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    3. NM_170987.8 → NP_740985.2  CREB homolog crh-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740985.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09636
      Conserved Domains (1) summary
      cd14689
      Location:156 → 216
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    4. NM_001306557.3 → NP_001293486.1  CREB homolog crh-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293486.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FD32
      Conserved Domains (1) summary
      cd14689
      Location:151 → 211
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version

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