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    col-109 Nematode cuticle collagen N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176988, updated on 9-Dec-2024

    Summary

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    Official Symbol
    col-109
    Official Full Name
    Nematode cuticle collagen N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00000683
    Locus tag
    CELE_Y38C1BA.3
    See related
    AllianceGenome:WB:WBGene00000683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cuticle. Involved in IRE1-mediated unfolded protein response. Predicted to be located in membrane. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See col-109 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (1817392..1820253, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene ATP-grasp domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Calcium/calmodulin-dependent protein kinase type 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C terminus of collagen SQT-3 has complex and essential functions in nematode collagen assembly. Novelli J, et al. Genetics, 2006 Apr. PMID 16452136, Free PMC Article
    2. Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli. Huang CR, et al. Nat Commun, 2021 Jan 4. PMID 33397943, Free PMC Article
    3. A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. Urano F, et al. J Cell Biol, 2002 Aug 19. PMID 12186849, Free PMC Article
    4. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nematode cuticle collagen N-terminal domain-containing protein
    NP_500138.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1817392..1820253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067737.6 → NP_500138.1  Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500138.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N527
      Conserved Domains (2) summary
      smart01088
      Location:12 → 63
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
      PRK07764
      Location:95 → 228
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
    Nucleotide Protein
    Heading Accession and Version

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