daz-1 DAZ protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: daz-1
Official Full Name: DAZ protein 1
Primary source: WormBase:WBGene00000935
Locus tag: CELE_F56D1.7
See related: AllianceGenome:WB:WBGene00000935
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA 3'-UTR binding activity and translation activator activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and positive regulation of translational initiation. Located in cytoplasm. Is expressed in germ line; gonad; and in male. Orthologous to several human genes including DAZ1 (deleted in azoospermia 1); DAZ2 (deleted in azoospermia 2); and DAZ3 (deleted in azoospermia 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See daz-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (5456305..5458609)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DAZ-1 binds and regulates the gld-1 mRNA.
Title: Identification of proteins and miRNAs that specifically bind an mRNA in vivo.
daz-1 plays a role upstream of the pathway for germ cell sex determination.
Title: The Caenorhabditis elegans homologue of deleted in azoospermia is involved in the sperm/oocyte switch.
all germline samples studied were found to be free from AZFc microdeletions and CNP of the DAZ genes.
Title: AZFc somatic microdeletions and copy number polymorphism of the DAZ genes in human males exposed to natural background radiation.
DAZ-1 in C. elegans plays essential roles in female premeiotic and early meiotic germ cells, probably via regulating the translational activity of specific target genes required for the progression of oogenesis.
Title: Caenorhabditis elegans DAZ-1 is expressed in proliferating germ cells and directs proper nuclear organization and cytoplasmic core formation during oogenesis.
in a two hybrid assay,daz- as bait interacted with cpb-3
Title: C. elegans CPB-3 interacts with DAZ-1 and functions in multiple steps of germline development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F56D1.5 (e-PCR)
- UniSTS:311867

STS2-243 (e-PCR)
- UniSTS:241919

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables translation activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DAZ protein 1

NP_495036.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5456305..5458609

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062635.5 → NP_495036.3 DAZ protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495036.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20870, Q9U5G2

Conserved Domains (2) summary

COG0724
Location:56 → 150

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12412
Location:64 → 145

RRM_DAZL_BOULE; RNA recognition motif in AZoospermia (DAZ) autosomal homologs, DAZL (DAZ-like) and BOULE