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    hmg-12 High mobility group protein hmg-12 [ Caenorhabditis elegans ]

    Gene ID: 174829, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hmg-12
    Official Full Name
    High mobility group protein hmg-12
    Primary source
    WormBase:WBGene00001977
    Locus tag
    CELE_Y17G7A.1
    See related
    AllianceGenome:WB:WBGene00001977
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II core promoter sequence-specific DNA binding activity. Involved in positive regulation of gene expression. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hmg-12 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003280.10 (11916513..11917643)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene non-specific serine/threonine protein kinase Neighboring gene RGS domain-containing protein Neighboring gene C2H2-type domain-containing protein;Zinc finger transcription factor lin-29 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of HMG-12 and CAR-1 in the cdc-48.1 expression of Caenorhabditis elegans. Yamauchi S, et al. Dev Biol, 2008 Jun 15. PMID 18430416
    2. Caudal-like PAL-1 directly activates the bodywall muscle module regulator hlh-1 in C. elegans to initiate the embryonic muscle gene regulatory network. Lei H, et al. Development, 2009 Apr. PMID 19261701, Free PMC Article
    3. DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Lin XX, et al. Nat Commun, 2018 Oct 23. PMID 30353013, Free PMC Article
    4. A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline. Colaiácovo MP, et al. Genetics, 2002 Sep. PMID 12242227, Free PMC Article
    5. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that both HMG-12 and CAR-1 play important roles in embryonic expression of cdc-48.1.
      Title: Involvement of HMG-12 and CAR-1 in the cdc-48.1 expression of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of macromolecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    High mobility group protein hmg-12
    NP_496544.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11916513..11917643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064143.8 → NP_496544.1  High mobility group protein hmg-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496544.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDQ2
      Conserved Domains (1) summary
      PTZ00108
      Location:91 → 287
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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