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    pho-5 Putative acid phosphatase 5 [ Caenorhabditis elegans ]

    Gene ID: 176030, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pho-5
    Official Full Name
    Putative acid phosphatase 5
    Primary source
    WormBase:WBGene00015161
    Locus tag
    CELE_B0361.7
    See related
    AllianceGenome:WB:WBGene00015161
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatase activity. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J and prostate cancer. Orthologous to human ACP2 (acid phosphatase 2, lysosomal); ACP3 (acid phosphatase 3); and ACP4 (acid phosphatase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pho-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (7283915..7285878, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative transporter B0361.11 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A systems biology-based identification and in vivo functional screening of Alzheimer's disease risk genes reveal modulators of memory function. Hudgins AD, et al. Neuron, 2024 Jul 3. PMID 38692279,
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Putative acid phosphatase 5
    NP_498604.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7283915..7285878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066203.8 → NP_498604.2  Putative acid phosphatase 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498604.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10944
      Conserved Domains (1) summary
      cd07061
      Location:30 → 320
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10944.3

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