ife-5 Eukaryotic translation initiation factor 4E-5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ife-5
Official Full Name: Eukaryotic translation initiation factor 4E-5
Primary source: WormBase:WBGene00002063
Locus tag: CELE_Y57A10A.30
See related: AllianceGenome:WB:WBGene00002063
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA 7-methylguanosine cap binding activity and RNA trimethylguanosine cap binding activity. Involved in embryo development. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in germ line. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ife-5 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 3

Sequence:: Chromosome: II; NC_003280.10 (12280660..12284139)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y57A10A.dd (e-PCR)
- UniSTS:323147

Y57A10A.ee (e-PCR)
- UniSTS:323149

STS2-199 (e-PCR)
- UniSTS:241872

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA 7-methylguanosine cap binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA 7-methylguanosine cap binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA trimethylguanosine cap binding	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NOT involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Eukaryotic translation initiation factor 4E-5

NP_001379255.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

12280660..12284139

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001393209.1 → NP_001379255.1 Eukaryotic translation initiation factor 4E-5 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P56570, Q9NIF2

Conserved Domains (1) summary

pfam01652
Location:10 → 159

IF4E; Eukaryotic initiation factor 4E