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    ntp-1 Nucleoside-triphosphatase ntp-1 [ Caenorhabditis elegans ]

    Gene ID: 177567, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ntp-1
    Official Full Name
    Nucleoside-triphosphatase ntp-1
    Primary source
    WormBase:WBGene00016380
    Locus tag
    CELE_C33H5.14
    See related
    AllianceGenome:WB:WBGene00016380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables pyrophosphatase activity. Involved in ribonucleotide metabolic process. Located in Golgi apparatus and perinuclear region of cytoplasm. Orthologous to human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4) and ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ntp-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (7792349..7794809, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene putative splicing factor, arginine/serine-rich 6 Neighboring gene CYSTM domain-containing protein Neighboring gene Shugoshin Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans. Uccelletti D, et al. J Biol Chem, 2004 Jun 25. PMID 15102851
    2. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in CTP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CTP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GDP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GTP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nucleoside-triphosphatase ntp-1
    NP_001294166.1
    • Confirmed by transcript evidence
    NP_001294167.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7792349..7794809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307238.2 → NP_001294167.1  Nucleoside-triphosphatase ntp-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294167.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18411, W6RRY0, W6RTH8
      Conserved Domains (1) summary
      pfam01150
      Location:74 → 492
      GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family

    2. NM_001307237.2 → NP_001294166.1  Nucleoside-triphosphatase ntp-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294166.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18411
      Conserved Domains (1) summary
      pfam01150
      Location:40 → 458
      GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18411.2

    Gene LinkOut

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