ilcr-2 Interleukin cytokine receptor-related protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ilcr-2
Official Full Name: Interleukin cytokine receptor-related protein 2
Primary source: WormBase:WBGene00018960
Locus tag: CELE_F56D1.2
See related: AllianceGenome:WB:WBGene00018960
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable interleukin-17 receptor activity. Involved in positive regulation of locomotion. Located in plasma membrane. Part of receptor complex. Is expressed in body wall musculature; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in immunodeficiency 51. Orthologous to human IL17RA (interleukin 17 receptor A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ilcr-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (5475246..5478526)

Chromosome II - NC_003280.10

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

clr-1 encodes a transmembrane receptor protein tyrosine phosphatase (RPTP) that functions in AVM to inhibit signaling through the DCC family receptor UNC-40 and its effector, UNC-34/enabled
Title: Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase.
EGL-15 and CLR-1 act in the hypodermis to regulate fluid homeostasis in worms
Title: FGF signaling functions in the hypodermis to regulate fluid balance in C. elegans.
Caenorhabditis elegans fibroblast growth factor receptor EGL-15 expression is required within epidermal cells and the substratum for most outgrowing axons, for appropriate outgrowth of specific axon classes to their target area.
Title: Differential functions of the C. elegans FGF receptor in axon outgrowth and maintenance of axon position.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F56D1.2 (e-PCR)
- UniSTS:311865

F56D1.3 (e-PCR)
- UniSTS:316818

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables interleukin-17 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-17 receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Interleukin cytokine receptor-related protein 2

NP_001022206.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5475246..5478526

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027035.6 → NP_001022206.1 Interleukin cytokine receptor-related protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022206.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10128

Conserved Domains (1) summary

pfam08357
Location:415 → 566

SEFIR; SEFIR domain