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    F45G2.9 rRNA methyltransferase 2, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 185813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F45G2.9
    Official Full Name
    rRNA methyltransferase 2, mitochondrial
    Primary source
    WormBase:WBGene00009735
    Locus tag
    CELE_F45G2.9
    See related
    AllianceGenome:WB:WBGene00009735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in RNA methylation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 17. Orthologous to human MRM2 (mitochondrial rRNA methyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F45G2.9 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (13435771..13436943, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene COMM domain-containing protein Neighboring gene Mitochondrial import inner membrane translocase subunit tim-16 Neighboring gene MIP18 family protein F45G2.10 Neighboring gene P-type Cu(+) transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (uridine-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rRNA methyltransferase 2, mitochondrial
    NP_499776.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13435771..13436943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067375.5 → NP_499776.1  rRNA methyltransferase 2, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499776.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62251
      Conserved Domains (1) summary
      COG0293
      Location:4 → 214
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62251.1

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