U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sam-4 BLOC-1-related complex subunit 5 [ Caenorhabditis elegans ]

    Gene ID: 173955, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sam-4
    Official Full Name
    BLOC-1-related complex subunit 5
    Primary source
    WormBase:WBGene00019126
    Locus tag
    CELE_F59E12.11
    See related
    AllianceGenome:WB:WBGene00019126
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including positive regulation of anterograde synaptic vesicle transport; positive regulation of nematode pharyngeal pumping; and regulation of growth. Located in synaptic vesicle membrane. Is expressed in nerve ring. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human BORCS5 (BLOC-1 related complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sam-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (5647982..5649286, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene TFIIS central domain-containing protein Neighboring gene WASH complex subunit homolog 3 Neighboring gene Anaphase-promoting complex subunit 13 Neighboring gene ncRNA Neighboring gene putative serine/threonine-protein kinase zyg-1 Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Preferential transport of synaptic vesicles across neuronal branches is regulated by the levels of the anterograde motor UNC-104/KIF1A in vivo. Vasudevan A, et al. Genetics, 2024 May 7. PMID 38467475,
    2. The vesicle protein SAM-4 regulates the processivity of synaptic vesicle transport. Zheng Q, et al. PLoS Genet, 2014 Oct. PMID 25329901, Free PMC Article
    3. BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-8. Niwa S, et al. Curr Biol, 2017 Sep 11. PMID 28823680, Free PMC Article
    4. Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Holzapfel R, et al. Eur J Cell Biol, 2024 Jun. PMID 38582051
    5. A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes. Fazeli G, et al. Curr Biol, 2023 Feb 27. PMID 36652947, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The vesicle protein SAM-4 regulates the processivity of synaptic vesicle transport.
      Title: The vesicle protein SAM-4 regulates the processivity of synaptic vesicle transport.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lysosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysosome localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organismal reproductive process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in organelle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of anterograde synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of anterograde synaptic vesicle transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of anterograde synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of nematode pharyngeal pumping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BORC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    BLOC-1-related complex subunit 5
    NP_001367525.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5647982..5649286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381430.3 → NP_001367525.1  BLOC-1-related complex subunit 5 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01902
      Conserved Domains (1) summary
      pfam10158
      Location:64 → 195
      LOH1CR12; tumor suppressor protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools