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    snn-1 ATP-grasp domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snn-1
    Official Full Name
    ATP-grasp domain-containing protein
    Primary source
    WormBase:WBGene00004913
    Locus tag
    CELE_Y38C1BA.2
    See related
    AllianceGenome:WB:WBGene00004913
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity. Involved in neuromuscular synaptic transmission. Located in presynaptic periactive zone. Is expressed in epithelial cell and nervous system. Human ortholog(s) of this gene implicated in X-linked epilepsy with variable learning disabilities and behavior disorders; non-syndromic X-linked intellectual disability 50; and schizophrenia. Orthologous to several human genes including SYN3 (synapsin III). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snn-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (1805027..1815118, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release. Yu SC, et al. J Neurosci, 2021 May 12. PMID 33820857, Free PMC Article
    2. Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin. Stavoe AK, et al. Genes Dev, 2012 Oct 1. PMID 23028145, Free PMC Article
    3. Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans. Arantes LP, et al. Toxicol Res (Camb), 2016 Nov 1. PMID 28316775, Free PMC Article
    4. Hierarchical assembly of presynaptic components in defined C. elegans synapses. Patel MR, et al. Nat Neurosci, 2006 Dec. PMID 17115039, Free PMC Article
    5. Synaptogenesis. Jin Y. WormBook, 2005 Dec 16. PMID 18050400, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release.
      Title: Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in presynaptic periactive zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-grasp domain-containing protein
    NP_001367951.1
    • Confirmed by transcript evidence
    NP_001367952.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1805027..1815118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380066.2 → NP_001367951.1  ATP-grasp domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGI2
      Conserved Domains (3) summary
      PRK14950
      Location:293 → 381
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      pfam02078
      Location:5 → 64
      Synapsin; N-terminal domain
      cl17255
      Location:95 → 288
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    2. NM_001380065.1 → NP_001367952.1  ATP-grasp domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXU3
      Conserved Domains (3) summary
      PRK14950
      Location:366 → 454
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      pfam02078
      Location:78 → 137
      Synapsin; N-terminal domain
      cl17255
      Location:168 → 361
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    Nucleotide Protein
    Heading Accession and Version

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