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    acs-13 Long-chain-fatty-acid--CoA ligase [ Caenorhabditis elegans ]

    Gene ID: 171643, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acs-13
    Official Full Name
    Long-chain-fatty-acid--CoA ligase
    Primary source
    WormBase:WBGene00022037
    Locus tag
    CELE_Y65B4BL.5
    See related
    AllianceGenome:WB:WBGene00022037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in body wall musculature; head; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congenital diarrhea; and leukemia. Orthologous to human ACSL1 (acyl-CoA synthetase long chain family member 1); ACSL5 (acyl-CoA synthetase long chain family member 5); and ACSL6 (acyl-CoA synthetase long chain family member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acs-13 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (511044..519646, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene P-granule-associated protein deps-1 Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene (Na+)-NQR maturation NqrM Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic titration of membrane composition in Caenorhabditis elegans reveals its importance for multiple cellular and physiological traits. Devkota R, et al. Genetics, 2021 Aug 26. PMID 34125894, Free PMC Article
    2. Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity. Ruiz M, et al. Elife, 2019 Nov 26. PMID 31769755, Free PMC Article
    3. Paradigm shift: the primary function of the "Adiponectin Receptors" is to regulate cell membrane composition. Pilon M. Lipids Health Dis, 2021 Apr 30. PMID 33931104, Free PMC Article
    4. Identification of CED-3 substrates by a yeast-based screening method. Kim SY, et al. Mol Biotechnol, 2004 May. PMID 15122042
    5. Dietary S. maltophilia induces supersized lipid droplets by enhancing lipogenesis and ER-LD contacts in C. elegans. Xie K, et al. Gut Microbes, 2022 Jan-Dec. PMID 35112996, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Long-chain-fatty-acid--CoA ligase
    NP_001293196.1
    • Confirmed by transcript evidence
    NP_001368382.1
    • Confirmed by transcript evidence
    NP_490744.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      511044..519646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058343.5 → NP_490744.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N302
      Conserved Domains (1) summary
      cd05927
      Location:140 → 716
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    2. NM_001306267.3 → NP_001293196.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293196.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLI5
      Conserved Domains (1) summary
      cd05927
      Location:147 → 723
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    3. NM_001379780.1 → NP_001368382.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CK48
      Conserved Domains (1) summary
      cd05927
      Location:97 → 673
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    Nucleotide Protein
    Heading Accession and Version

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