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    cogc-1 Conserved oligomeric Golgi complex subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 3565555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cogc-1
    Official Full Name
    Conserved oligomeric Golgi complex subunit 1
    Primary source
    WormBase:WBGene00003258
    Locus tag
    CELE_Y54E10A.2
    See related
    AllianceGenome:WB:WBGene00003258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including gonad morphogenesis; regulation of cell migration; and vulval development. Predicted to be located in membrane. Predicted to be part of Golgi transport complex. Predicted to be active in Golgi apparatus. Is expressed in germ line. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIg. Orthologous to human COG1 (component of oligomeric golgi complex 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cogc-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (3233391..3256077)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CDT1 Geminin-binding domain-containing protein Neighboring gene Thioredoxin-like protein Neighboring gene Male abnormal protein mab-31 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans as a model system to study the function of the COG complex in animal development. Kubota Y, et al. Biol Chem, 2006 Aug. PMID 16895472
    2. mab-31 and the TGF-beta pathway act in the ray lineage to pattern C. elegans male sensory rays. Wong YF, et al. BMC Dev Biol, 2010 Aug 5. PMID 20687916, Free PMC Article
    3. The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans. Kubota Y, et al. Development, 2006 Jan. PMID 16354716
    4. DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Pinkston-Gosse J, et al. Nat Genet, 2007 Nov. PMID 17934462
    5. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Conserved oligomeric Golgi complex subunit 1
    NP_491128.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3233391..3256077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058727.7 → NP_491128.4  Conserved oligomeric Golgi complex subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491128.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE66
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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