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    lpd-3 Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lpd-3
    Official Full Name
    Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00003060
    Locus tag
    CELE_Y47G6A.23
    See related
    AllianceGenome:WB:WBGene00003060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in membrane and presynapse. Is expressed in intestine. Human ortholog(s) of this gene implicated in Alkuraya-Kucinskas syndrome. Orthologous to human BLTP1 (bridge-like lipid transfer protein family member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lpd-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    31
    Sequence:
    Chromosome: I; NC_003279.8 (3564963..3600735, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DeHydrogenases, Short chain Neighboring gene pseudo Neighboring gene DeHydrogenases, Short chain Neighboring gene C6 domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene RING-type domain-containing protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bridge-Like Lipid Transfer Proteins (BLTPs) in C. elegans: From Genetics to Structures and Functions. Pandey T, et al. Contact (Thousand Oaks), 2023 Jan-Dec. PMID 37455813, Free PMC Article
    2. Vps13-like proteins provide phosphatidylethanolamine for GPI anchor synthesis in the ER. Toulmay A, et al. J Cell Biol, 2022 Mar 7. PMID 35015055, Free PMC Article
    3. C elegans: a model for exploring the genetics of fat storage. McKay RM, et al. Dev Cell, 2003 Jan. PMID 12530969, Free PMC Article
    4. LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans. Pandey T, et al. Cell Rep, 2024 Mar 26. PMID 38446666, Free PMC Article
    5. A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience. Wang C, et al. Nat Commun, 2022 Nov 10. PMID 36357390, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans.
      Title: LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein
    NP_001300464.1
    • Confirmed by transcript evidence
    NP_001300465.1
    • Confirmed by transcript evidence
    NP_001300466.1
    • Confirmed by transcript evidence
    NP_001300467.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3564963..3600735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313535.2 → NP_001300464.1  Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ATS5
      Conserved Domains (1) summary
      pfam10479
      Location:3363 → 3860
      FSA_C; Fragile site-associated protein C-terminus

    2. NM_001313538.2 → NP_001300467.1  Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWP8
      Conserved Domains (1) summary
      pfam10479
      Location:3367 → 3864
      FSA_C; Fragile site-associated protein C-terminus

    3. NM_001313537.3 → NP_001300466.1  Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUC6
      Conserved Domains (1) summary
      pfam10479
      Location:3365 → 3862
      FSA_C; Fragile site-associated protein C-terminus

    4. NM_001313536.3 → NP_001300465.1  Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AQT9
      Conserved Domains (1) summary
      pfam10479
      Location:3365 → 3862
      FSA_C; Fragile site-associated protein C-terminus
    Nucleotide Protein
    Heading Accession and Version

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