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    cpi-2 Cystatin cpi-2 [ Caenorhabditis elegans ]

    Gene ID: 178992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpi-2
    Official Full Name
    Cystatin cpi-2
    Primary source
    WormBase:WBGene00000534
    Locus tag
    CELE_R01B10.1
    See related
    AllianceGenome:WB:WBGene00000534
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cysteine-type endopeptidase inhibitor activity. Involved in positive regulation of vitellogenesis; regulation of oocyte development; and regulation of protein processing. Located in extracellular space and yolk granule. Is expressed in hypodermis; intestine; pharyngeal gland cell; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy; age related macular degeneration 11; and ectodermal dysplasia 15. Orthologous to several human genes including CST3 (cystatin C); CST5 (cystatin D); and CST6 (cystatin E/M). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpi-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (6044062..6045664)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Solute carrier family 3 member 2 N-terminal domain-containing protein Neighboring gene Post-GPI attachment to proteins factor 3 Neighboring gene JNK1/MAPK8-associated membrane protein homolog Neighboring gene Seipin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing. Manoury B, et al. Curr Biol, 2001 Mar 20. PMID 11301256
    2. Parasite-specific immunomodulatory functions of filarial cystatin. Schierack P, et al. Infect Immun, 2003 May. PMID 12704112, Free PMC Article
    3. Developing a rapid throughput screen for detection of nematicidal activity of plant cysteine proteinases: the role of Caenorhabditis elegans cystatins. Phiri AM, et al. Parasitology, 2014 Feb. PMID 24001183
    4. Cystatins from filarial parasites: evolution, adaptation and function in the host-parasite relationship. Gregory WF, et al. Int J Biochem Cell Biol, 2008. PMID 18249028
    5. The Caenorhabditis elegans CPI-2a cystatin-like inhibitor has an essential regulatory role during oogenesis and fertilization. Hashmi S, et al. J Biol Chem, 2006 Sep 22. PMID 16857685

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wild-type Caenorhabditis elegans deploy cystatins CPI-1 and CPI-2 to resist cysteine proteinase (CP) attack.
      Title: Developing a rapid throughput screen for detection of nematicidal activity of plant cysteine proteinases: the role of Caenorhabditis elegans cystatins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of vitellogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of oocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in yolk granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cystatin cpi-2
    NP_504565.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6044062..6045664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072164.9 → NP_504565.1  Cystatin cpi-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504565.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECM9
      Conserved Domains (1) summary
      smart00043
      Location:21 → 126
      CY; Cystatin-like domain

    RNA

    1. NR_138504.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECM9.1

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