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    tsen-54 tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176994, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tsen-54
    Official Full Name
    tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00018680
    Locus tag
    CELE_F52C12.3
    See related
    AllianceGenome:WB:WBGene00018680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2A; pontocerebellar hypoplasia type 4; and pontocerebellar hypoplasia type 5. Orthologous to human TSEN54 (tRNA splicing endonuclease subunit 54). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tsen-54 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (1948191..1953317)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transcription factor elt-6 Neighboring gene DENN domain type RAB GEF Neighboring gene 18S rRNA aminocarboxypropyltransferase Neighboring gene Protein kinase domain-containing protein;non-specific serine/threonine protein kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-type intron splice site recognition and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of tRNA-intron endonuclease complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein
    NP_500146.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1948191..1953317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067745.6 → NP_500146.1  tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500146.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TXV5
      Conserved Domains (1) summary
      pfam12928
      Location:28 → 63
      tRNA_int_end_N2; tRNA-splicing endonuclease subunit sen54 N-term
    Nucleotide Protein
    Heading Accession and Version

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