ubr-4 UBR-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ubr-4
Official Full Name: UBR-type domain-containing protein
Primary source: WormBase:WBGene00016650
Locus tag: CELE_C44E4.1
See related: AllianceGenome:WB:WBGene00016650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in DNA replication. Orthologous to human UBR4 (ubiquitin protein ligase E3 component n-recognin 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ubr-4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 21

Sequence:: Chromosome: I; NC_003279.8 (4610143..4633347, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ubiquitin ligase Ubr4 is responsible for the degradation of mislocalized MEC-2 multimers. Ubiquitylation of one MEC-2 site, K301, do not only target MEC-2 for proteasomal degradation, but may also affect stability and disassembly of the multimeric complex.
Title: The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C44E4.1 (e-PCR)
- UniSTS:317462

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UBR-type domain-containing protein

NP_001305200.1

Confirmed by transcript evidence

NP_491407.2

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4610143..4633347 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059006.3 → NP_491407.2 UBR-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491407.2

Status: REVIEWED

UniProtKB/TrEMBL

O01808

Conserved Domains (3) summary

pfam02916
Location:1504 → 1615

DNA_PPF; DNA polymerase processivity factor

pfam13764
Location:3431 → 4197

E3_UbLigase_R4; E3 ubiquitin-protein ligase UBR4

cd19674
Location:1214 → 1279

UBR-box_UBR4_like; UBR-box found in RING-type E3 ubiquitin-protein ligase UBR4 and similar proteins
NM_001318271.2 → NP_001305200.1 UBR-type domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S4XR36

Conserved Domains (3) summary

smart00396
Location:1221 → 1286

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

pfam02916
Location:1510 → 1622

DNA_PPF; DNA polymerase processivity factor

pfam13764
Location:3438 → 4202

E3_UbLigase_R4; E3 ubiquitin-protein ligase UBR4