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    cyp-35A1 CYtochrome P450 family [ Caenorhabditis elegans ]

    Gene ID: 182176, updated on 27-Dec-2024

    Summary

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    Official Symbol
    cyp-35A1
    Official Full Name
    CYtochrome P450 family
    Primary source
    WormBase:WBGene00015399
    Locus tag
    CELE_C03G6.14
    See related
    AllianceGenome:WB:WBGene00015399
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in response to xenobiotic stimulus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); drug dependence (multiple); gastrointestinal system cancer (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)); and CYP2E1 (cytochrome P450 family 2 subfamily E member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyp-35A1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (7359929..7361773, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein Neighboring gene Methyltransferase FkbM domain-containing protein Neighboring gene CYtochrome P450 family Neighboring gene Excretory canal abnormal exc-13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis Elegans Mutants Predict Regulation of Fatty Acids and Endocannabinoids by the CYP-35A Gene Family. Aarnio V, et al. Front Pharmacol, 2011. PMID 21687507, Free PMC Article
    2. Expression profiling of five different xenobiotics using a Caenorhabditis elegans whole genome microarray. Reichert K, et al. Chemosphere, 2005 Oct. PMID 16168746
    3. CYP35: xenobiotically induced gene expression in the nematode Caenorhabditis elegans. Menzel R, et al. Arch Biochem Biophys, 2005 Jun 1. PMID 15910738
    4. Toxicity and metabolism of 3-bromopyruvate in Caenorhabditis elegans. Gu QL, et al. J Zhejiang Univ Sci B, 2020 Jan.. PMID 31898444, Free PMC Article
    5. A systematic gene expression screen of Caenorhabditis elegans cytochrome P450 genes reveals CYP35 as strongly xenobiotic inducible. Menzel R, et al. Arch Biochem Biophys, 2001 Nov 15. PMID 11697852

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to xenobiotic stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CYtochrome P450 family
    NP_001343612.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7359929..7361773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356694.2 → NP_001343612.1  CYtochrome P450 family [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02627
      Conserved Domains (1) summary
      cl12078
      Location:26 → 466
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version

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