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    cmtr-1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [ Caenorhabditis elegans ]

    Gene ID: 175156, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cmtr-1
    Official Full Name
    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Primary source
    WormBase:WBGene00013160
    Locus tag
    CELE_Y53F4B.13
    See related
    AllianceGenome:WB:WBGene00013160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be active in cytoplasm and nucleus. Orthologous to human CMTR1 (cap methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cmtr-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (15026114..15037854)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Amino acid permease/ SLC12A domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein PET100 homolog, mitochondrial;TPX2 domain-containing protein Neighboring gene TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene. Meisel JD, et al. Curr Biol, 2024 Jun 17. PMID 38810637, Free PMC Article
    2. An actin-based viscoplastic lock ensures progressive body-axis elongation. Lardennois A, et al. Nature, 2019 Sep. PMID 31462781, Free PMC Article
    3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 7-methylguanosine mRNA capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 7-methylguanosine mRNA capping ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    NP_001254457.1
    • Confirmed by transcript evidence
    NP_001254458.1
    • Confirmed by transcript evidence
    NP_001254459.1
    • Partially confirmed by transcript evidence
    NP_001254460.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      15026114..15037854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267528.2 → NP_001254457.1  Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254457.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H8ESH8, H8ESH9, H8ESI0, H8ESI1, Q9NAA5
      Conserved Domains (2) summary
      pfam01585
      Location:89 → 130
      G-patch; G-patch domain
      pfam01728
      Location:237 → 463
      FtsJ; FtsJ-like methyltransferase

    2. NM_001267529.3 → NP_001254458.1  Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254458.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NAA5
      Conserved Domains (2) summary
      pfam01585
      Location:89 → 130
      G-patch; G-patch domain
      pfam01728
      Location:237 → 457
      FtsJ; FtsJ-like methyltransferase

    3. NM_001267530.3 → NP_001254459.1  Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254459.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NAA5
      Conserved Domains (2) summary
      pfam01585
      Location:89 → 130
      G-patch; G-patch domain
      pfam01728
      Location:237 → 463
      FtsJ; FtsJ-like methyltransferase

    4. NM_001267531.3 → NP_001254460.1  Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254460.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NAA5
      Conserved Domains (2) summary
      pfam01585
      Location:89 → 130
      G-patch; G-patch domain
      pfam01728
      Location:237 → 463
      FtsJ; FtsJ-like methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NAA5.3

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