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    afmd-2 Abhydrolase_3 domain-containing protein;Alpha/beta hydrolase fold-3 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189911, updated on 9-Dec-2024

    Summary

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    Official Symbol
    afmd-2
    Official Full Name
    Abhydrolase_3 domain-containing protein;Alpha/beta hydrolase fold-3 domain-containing protein
    Primary source
    WormBase:WBGene00012866
    Locus tag
    CELE_Y45F10A.3
    See related
    AllianceGenome:WB:WBGene00012866
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hydrolase activity. Predicted to be involved in tryptophan catabolic process to kynurenine. Predicted to be active in cytoplasm. Orthologous to human AFMID (arylformamidase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See afmd-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (13509224..13513433)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene putative selenide, water dikinase Neighboring gene PUM-HD domain-containing protein Neighboring gene m7GpppN-mRNA hydrolase dcap-2 Neighboring gene AF-9 ANC1 homology domain-containing protein;RSD-2 domain-containing protein Neighboring gene ncRNA Neighboring gene RSD-2 N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tryptophan catabolic process to kynurenine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Abhydrolase_3 domain-containing protein;Alpha/beta hydrolase fold-3 domain-containing protein
    NP_001293952.1
    • Confirmed by transcript evidence
    NP_001293953.1
    • Confirmed by transcript evidence
    NP_502605.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13509224..13513433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070204.3 → NP_502605.2  Alpha/beta hydrolase fold-3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502605.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62460
      Conserved Domains (1) summary
      COG0657
      Location:26 → 173
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

    2. NM_001307023.3 → NP_001293952.1  Alpha/beta hydrolase fold-3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293952.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AJ76
      Conserved Domains (1) summary
      COG0657
      Location:3 → 118
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

    3. NM_001307024.1 → NP_001293953.1  Abhydrolase_3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293953.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AKW2
    Nucleotide Protein
    Heading Accession and Version

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