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    smg-8 Nonsense-mediated mRNA decay factor SMG8 [ Caenorhabditis elegans ]

    Gene ID: 175103, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smg-8
    Official Full Name
    Nonsense-mediated mRNA decay factor SMG8
    Primary source
    WormBase:WBGene00010551
    Locus tag
    CELE_K04B12.3
    See related
    AllianceGenome:WB:WBGene00010551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in striated muscle dense body. Orthologous to human SMG8 (SMG8 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smg-8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (14441409..14447233)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene snRNA-activating protein complex subunit 3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins. Li L, et al. RNA, 2017 Jul. PMID 28389433, Free PMC Article
    2. Genetic characterization of smg-8 mutants reveals no role in C. elegans nonsense mediated decay. Rosains J, et al. PLoS One, 2012. PMID 23166684, Free PMC Article
    3. Caenorhabditis elegans algn-2 Is Critical for Longevity Conferred by Enhanced Nonsense-Mediated mRNA Decay. Kim EJE, et al. iScience, 2020 Nov 20. PMID 33225240, Free PMC Article
    4. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Yamashita A, et al. Genes Dev, 2009 May 1. PMID 19417104, Free PMC Article
    5. AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. Izumi N, et al. Sci Signal, 2010 Apr 6. PMID 20371770

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    Nonsense-mediated mRNA decay factor SMG8
    NP_001293559.1
    • Confirmed by transcript evidence
    NP_001293560.1
    • Confirmed by transcript evidence
    NP_497003.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14441409..14447233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064602.6 → NP_497003.3  Nonsense-mediated mRNA decay factor SMG8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497003.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62301
      Conserved Domains (1) summary
      pfam10220
      Location:19 → 860
      DUF2146; Uncharacterized conserved protein (DUF2146)

    2. NM_001306630.5 → NP_001293559.1  Nonsense-mediated mRNA decay factor SMG8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEH8
      Conserved Domains (1) summary
      pfam10220
      Location:19 → 858
      DUF2146; Uncharacterized conserved protein (DUF2146)

    3. NM_001306631.3 → NP_001293560.1  Nonsense-mediated mRNA decay factor SMG8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293560.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBA4
      Conserved Domains (1) summary
      pfam14413
      Location:212 → 233
      Thg1C; Thg1 C terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62301.3

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