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    mut-16 MUTator [ Caenorhabditis elegans ]

    Gene ID: 172873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mut-16
    Official Full Name
    MUTator
    Primary source
    WormBase:WBGene00003508
    Locus tag
    CELE_B0379.3
    See related
    AllianceGenome:WB:WBGene00003508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in regulatory ncRNA-mediated post-transcriptional gene silencing and siRNA processing. Located in mutator focus and nucleus. Is expressed in several structures, including germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mut-16 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    14
    Sequence:
    Chromosome: I; NC_003279.8 (10080159..10085765)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene CTD small phosphatase-like protein 1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endogenous RNAi Pathways Are Required in Neurons for Dauer Formation in Caenorhabditis elegans. Bharadwaj PS, et al. Genetics, 2017 Apr. PMID 28122825, Free PMC Article
    2. Tissue-specific silencing of integrated transgenes achieved through endogenous RNA interference in Caenorhabditis elegans. Chen S, et al. RNA Biol, 2024 Jan. PMID 38531838, Free PMC Article
    3. RNAi pathways repress reprogramming of C. elegans germ cells during heat stress. Rogers AK, et al. Nucleic Acids Res, 2020 May 7. PMID 32187370, Free PMC Article
    4. Caenorhabditis elegans germ granules are present in distinct configurations and assemble in a hierarchical manner. Uebel CJ, et al. Development, 2023 Dec 15. PMID 38009921, Free PMC Article
    5. mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Zhang C, et al. Proc Natl Acad Sci U S A, 2011 Jan 25. PMID 21245313, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study demonstrate that in C. elegans the assembly of the Mutator complex and the formation of Mutator foci are mediated by the intrinsically disordered protein MUT-16.
      Title: Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci.
    2. MUT-16 is required for expression of a subset of G proteins with functions in the detection of pheromone components.
      Title: Endogenous RNAi Pathways Are Required in Neurons for Dauer Formation in Caenorhabditis elegans.
    3. demonstrate that genes that yield high levels of siRNAs, indicative of multiple rounds of siRNA amplification, are disproportionally affected in mut-16 mutants compared with genes that yield low levels of siRNAs
      Title: MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline.
    4. Results indicate that mut-16 is an essential factor in multiple endogenous germline and somatic siRNA pathways.
      Title: mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mutator focus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MUTator
    NP_492660.3
    • Product from WormBase gene class mut;
      Confirmed by transcript evidence
    NP_492661.3
    • Product from WormBase gene class mut;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10080159..10085765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060260.9 → NP_492661.3  MUTator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492661.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3S5
      Conserved Domains (2) summary
      pfam07223
      Location:609 → 954
      DUF1421; Protein of unknown function (DUF1421)
      pfam15794
      Location:469 → 609
      CCDC106; Coiled-coil domain-containing protein 106

    2. NM_060259.7 → NP_492660.3  MUTator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492660.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62011
      Conserved Domains (2) summary
      pfam07223
      Location:613 → 958
      DUF1421; Protein of unknown function (DUF1421)
      pfam15794
      Location:473 → 613
      CCDC106; Coiled-coil domain-containing protein 106
    Nucleotide Protein
    Heading Accession and Version

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