rde-8 RNase NYN domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rde-8
Official Full Name: RNase NYN domain-containing protein
Primary source: WormBase:WBGene00022620
Locus tag: CELE_ZC477.5
See related: AllianceGenome:WB:WBGene00022620
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA endonuclease activity and mRNA binding activity. Involved in siRNA processing. Located in mutator focus. Is expressed in germ line. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rde-8 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (7101379..7103261, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings suggest a model in which RDE-8 cleaves target mRNAs to mediate silencing, while generating 3' uridylated mRNA fragments to serve as templates for the RNA-dependent RNA polymerase-directed amplification of the silencing signal.
Title: A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC477.5 (e-PCR)
- UniSTS:307057

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in siRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info
located_in mutator focus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNase NYN domain-containing protein

NP_501107.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7101379..7103261 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068706.6 → NP_501107.1 RNase NYN domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501107.1

Status: REVIEWED

UniProtKB/TrEMBL

Q23342

Conserved Domains (1) summary

pfam11977
Location:69 → 216

RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain