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    htp-3 HORMA domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172099, updated on 9-Dec-2024

    Summary

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    Official Symbol
    htp-3
    Official Full Name
    HORMA domain-containing protein
    Primary source
    WormBase:WBGene00002034
    Locus tag
    CELE_F57C9.5
    See related
    AllianceGenome:WB:WBGene00002034
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in homologous chromosome pairing at meiosis and meiotic DNA double-strand break formation. Located in chromatin and lateral element. Is expressed in embryonic cell; germ line; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See htp-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (4827072..4829791)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene EthanolaminePhosphoTransferase 1 homolog Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Twenty One u-rna (21U-RNA) biogenesis Fouled Up Neighboring gene C2H2-type domain-containing protein Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 6;Biogenesis of lysosome-related organelles complex 1 subunit 7 Neighboring gene C-type LECtin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PUF-8 facilitates homologous chromosome pairing by promoting proteasome activity during meiotic entry in C. elegans. Kumar GA, et al. Development, 2018 Mar 29. PMID 29540500
    2. DNA damage during meiosis induces chromatin remodeling and synaptonemal complex disassembly. Couteau F, et al. Dev Cell, 2011 Mar 15. PMID 21397846
    3. The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression. Silva N, et al. Dev Cell, 2014 Nov 24. PMID 25455309
    4. Phosphorylation of HORMA-domain protein HTP-3 at Serine 285 is dispensable for crossover formation. Das D, et al. G3 (Bethesda), 2022 May 6. PMID 35389463, Free PMC Article
    5. CRL2(LRR-1) E3-ligase regulates proliferation and progression through meiosis in the Caenorhabditis elegans germline. Burger J, et al. PLoS Genet, 2013 Mar. PMID 23555289, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HTP-3 recruits all known AE components to meiotic chromosomes and promotes cohesin loading, the first known involvement of an AE protein in this process
      Title: The axial element protein HTP-3 promotes cohesin loading and meiotic axis assembly in C. elegans to implement the meiotic program of chromosome segregation.
    2. The meiotic axis component HTP-3 links double-strand breaks formation with homolog pairing and synapsis.
      Title: HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA double-strand break formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic DNA double-strand break formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lateral element IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HORMA domain-containing protein
    NP_491458.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4827072..4829791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059057.7 → NP_491458.1  HORMA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491458.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01820
      Conserved Domains (2) summary
      cl28054
      Location:358 → 530
      Pox_Ag35; Pox virus Ag35 surface protein
      pfam02301
      Location:37 → 222
      HORMA; HORMA domain
    Nucleotide Protein
    Heading Accession and Version

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