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    set-18 Histone-lysine N-methyltransferase set-18 [ Caenorhabditis elegans ]

    Gene ID: 172949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    set-18
    Official Full Name
    Histone-lysine N-methyltransferase set-18
    Primary source
    WormBase:WBGene00044070
    Locus tag
    CELE_T22A3.4
    See related
    AllianceGenome:WB:WBGene00044070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables histone H3K36 methyltransferase activity. Predicted to be involved in chromatin remodeling. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is expressed in body wall musculature; muscle cell; pharynx; and vulva. Orthologous to several human genes including SMYD1 (SET and MYND domain containing 1) and SMYD3 (SET and MYND domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See set-18 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (10590703..10593968)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SHSP domain-containing protein Neighboring gene Lateral signaling target 1 protein Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene Cilia- and flagella-associated protein 157 Neighboring gene Kringle domain-containing protein Neighboring gene DRBM domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression. Su L, et al. Cell Rep, 2018 Mar 6. PMID 29514099
    2. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
    3. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Greer EL, et al. Nature, 2010 Jul 15. PMID 20555324, Free PMC Article
    4. Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development. Andersen EC, et al. Development, 2007 Aug. PMID 17634190
    5. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SET-18 deletion extended lifespan and increased oxidative stress resistance, dependent on daf-16 activity in the insulin/IGF pathway.
      Title: Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone H3K36 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcomere HDA PubMed 
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    Histone-lysine N-methyltransferase set-18
    NP_492772.1
    • Confirmed by transcript evidence
    NP_871849.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10590703..10593968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060371.5 → NP_492772.1  Histone-lysine N-methyltransferase set-18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91821
      Conserved Domains (2) summary
      pfam01753
      Location:49 → 90
      zf-MYND; MYND finger
      cl40432
      Location:82 → 274
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

    2. NM_182049.7 → NP_871849.1  Histone-lysine N-methyltransferase set-18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871849.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91821, Q8I4F7
      Conserved Domains (2) summary
      pfam01753
      Location:49 → 90
      zf-MYND; MYND finger
      cl40432
      Location:82 → 274
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I4F7.1

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