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    tbx-43 T-box domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 4363053, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbx-43
    Official Full Name
    T-box domain-containing protein
    Primary source
    WormBase:WBGene00044798
    Locus tag
    CELE_Y46E12A.4
    See related
    AllianceGenome:WB:WBGene00044798
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance and primary immunodeficiency disease. Orthologous to human TBX21 (T-box transcription factor 21). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tbx-43 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (1765407..1770093, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF72 domain-containing protein Neighboring gene CaeNaCin (Caenorhabditis bacteriocin) Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TLDc domain-containing protein Neighboring gene ncRNA Neighboring gene C4-dicarboxylate ABC transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Levin M, et al. Dev Cell, 2012 May 15. PMID 22560298
    2. Transcriptomic Signature of the Simulated Microgravity Response in Caenorhabditis elegans and Comparison to Spaceflight Experiments. Çelen İ, et al. Cells, 2023 Jan 10. PMID 36672205, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-box domain-containing protein
    NP_001040883.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      1765407..1770093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047418.4 → NP_001040883.1  T-box domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040883.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1T6W8
      Conserved Domains (2) summary
      pfam00907
      Location:5 → 183
      T-box; T-box
      pfam15323
      Location:170 → 221
      Ashwin; Developmental protein
    Nucleotide Protein
    Heading Accession and Version

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