egl-45 Eukaryotic translation initiation factor 3 subunit A [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: egl-45
Official Full Name: Eukaryotic translation initiation factor 3 subunit A
Primary source: WormBase:WBGene00001209
Locus tag: CELE_C27D11.1
See related: AllianceGenome:WB:WBGene00001209
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA binding activity and translation regulator activity. Predicted to contribute to translation initiation factor activity. Involved in egg-laying behavior and embryo development. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3e; eukaryotic translation initiation factor 3 complex, eIF3m; and multi-eIF complex. Is expressed in neurons. Orthologous to human EIF3A (eukaryotic translation initiation factor 3 subunit A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See egl-45 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (7824377..7828626, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS3-166 (e-PCR)
- UniSTS:242008

C27D11.1 (e-PCR)
- UniSTS:308651

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translational initiation	IEA Inferred from Electronic Annotation more info
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in formation of cytoplasmic translation initiation complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translation reinitiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex, eIF3e	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex, eIF3m	IBA Inferred from Biological aspect of Ancestor more info
part_of multi-eIF complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Eukaryotic translation initiation factor 3 subunit A

NP_498698.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7824377..7828626 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066297.7 → NP_498698.1 Eukaryotic translation initiation factor 3 subunit A [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498698.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34339

Conserved Domains (3) summary

smart00753
Location:431 → 502

PAM; PCI/PINT associated module

cd16269
Location:670 → 687

GBP_C; coiled coil [structural motif]

cl20817
Location:608 → 706

GBP_C; Guanylate-binding protein, C-terminal domain