zfp-1 Zinc finger protein zfp-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: zfp-1
Official Full Name: Zinc finger protein zfp-1
Primary source: WormBase:WBGene00006975
Locus tag: CELE_F54F2.2
See related: AllianceGenome:WB:WBGene00006975
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables chromatin binding activity and methylated histone binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in condensed chromosome and nucleus. Is expressed in several structures, including germ line; intestine; oocyte; pharynx; and seam cell. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor) and MLLT6 (MLLT6, PHD finger containing). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See zfp-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 16

Sequence:: Chromosome: III; NC_003281.10 (8791827..8806305)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

zfp-1 is required for the enhanced longevity observed during dietary restriction and on knockdown of Insulin/IGF-1-like signalling.
Title: A chromatin modifier integrates insulin/IGF-1 signalling and dietary restriction to regulate longevity.
DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans.
Title: DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans.
the coordinated activities of DAF-16, ZFP-1, and endogenous RNAi contribute to gene regulation during development to ensure proper neuronal positioning
Title: Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans.
Recruitment of ZFP-1/DOT-1.1 and deposition of H3K79 methylation at highly expressed genes initiates a negative feedback mechanism for the modulation of their expression.
Title: The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription.
ZFP-1 localization peaks overlap with H3K4 methylation-enriched promoters of actively expressed genes genomewide and that H3K4 methylation is important for ZFP-1 localization to promoters in the embryo.
Title: The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans.
We found that the function of ZFP-1 in modulating pdk-1 transcription was important for the extended lifespan of the age-1(hx546) reduction-of-function PI3 kinase mutant.
Title: A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54F2.6 (e-PCR)
- UniSTS:315925

F54F2.4 (e-PCR)
- UniSTS:305972

STS3-174 (e-PCR)
- UniSTS:242017

F54F2.3 (e-PCR)
- UniSTS:305633

F54F2.2 (e-PCR)
- UniSTS:311790

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MOZ/MORF histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Zinc finger protein zfp-1

NP_001022610.1

Confirmed by transcript evidence

NP_001370728.1

Confirmed by transcript evidence

NP_001379957.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8791827..8806305

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027439.2 → NP_001022610.1 Zinc finger protein zfp-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022610.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34449
NM_001392166.1 → NP_001379957.1 Zinc finger protein zfp-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

G8JYB8, P34447, P34448, P34449

UniProtKB/TrEMBL

Q10652

Conserved Domains (3) summary

cd15574
Location:7 → 54

PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17

cd15672
Location:72 → 185

ePHD_AF10_like; Extended PHD finger found in protein AF-10 and AF-17

cd20901
Location:593 → 654

CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
NM_001382948.2 → NP_001370728.1 Zinc finger protein zfp-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd20901
Location:361 → 422

CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins