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    F52C12.6 Protein kinase domain-containing protein;non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

    Gene ID: 13192290, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F52C12.6
    Official Full Name
    Protein kinase domain-containing protein;non-specific serine/threonine protein kinase
    Primary source
    WormBase:WBGene00138717
    Locus tag
    CELE_F52C12.6
    See related
    AllianceGenome:WB:WBGene00138717
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in tRNA threonylcarbamoyladenosine metabolic process. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 4. Orthologous to human TP53RK (TP53 regulating kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F52C12.6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (1956711..1959760)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein Neighboring gene 18S rRNA aminocarboxypropyltransferase Neighboring gene Tyrosyl-DNA phosphodiesterase 1;UBC core domain-containing protein;putative tyrosyl-DNA phosphodiesterase Neighboring gene Ubiquitin-like protease family profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein;non-specific serine/threonine protein kinase
    NP_001255237.1
    • Confirmed by transcript evidence
    NP_001368243.1
    • Confirmed by transcript evidence
    NP_001380138.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1956711..1959760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268308.3 → NP_001255237.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255237.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5WWL2
      Conserved Domains (1) summary
      cl21453
      Location:30 → 245
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001380069.2 → NP_001368243.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBM5
      Conserved Domains (1) summary
      cl21453
      Location:1 → 140
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001392261.1 → NP_001380138.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PM30
      Conserved Domains (1) summary
      cl21453
      Location:1 → 33
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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