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    sms-3 Putative phosphatidylcholine:ceramide cholinephosphotransferase 3;Sphingomyelin synthase-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175313, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sms-3
    Official Full Name
    Putative phosphatidylcholine:ceramide cholinephosphotransferase 3;Sphingomyelin synthase-like domain-containing protein
    Primary source
    WormBase:WBGene00004894
    Locus tag
    CELE_Y22D7AL.8
    See related
    AllianceGenome:WB:WBGene00004894
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sms-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (1583155..1601144, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Talin_middle domain-containing protein Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Met Neighboring gene tRNA-Glu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism. Meister P, et al. Genome Biol, 2011 Dec 20. PMID 22185090, Free PMC Article
    2. Sphingolipid profiling reveals differential functions of sphingolipid biosynthesis isozymes of Caenorhabditis elegans. Luo H, et al. J Lipid Res, 2024 Jun. PMID 38704027, Free PMC Article
    3. Identification of a family of animal sphingomyelin synthases. Huitema K, et al. EMBO J, 2004 Jan 14. PMID 14685263, Free PMC Article
    4. The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans. Takagaki N, et al. EMBO Rep, 2020 Mar 4. PMID 32009302, Free PMC Article
    5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ceramide cholinephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide cholinephosphotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingomyelin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingomyelin synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingomyelin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingomyelin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Putative phosphatidylcholine:ceramide cholinephosphotransferase 3;Sphingomyelin synthase-like domain-containing protein
    NP_001317879.1
    • Confirmed by transcript evidence
    NP_001317880.1
    • Confirmed by transcript evidence
    NP_001317881.1
    • Confirmed by transcript evidence
    NP_001317882.1
    • Confirmed by transcript evidence
    NP_001380062.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      1583155..1601144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393283.1 → NP_001380062.1  Putative phosphatidylcholine:ceramide cholinephosphotransferase 3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q965Q4
      Conserved Domains (1) summary
      pfam14360
      Location:174 → 247
      PAP2_C; PAP2 superfamily C-terminal

    2. NM_001330977.3 → NP_001317879.1  Sphingomyelin synthase-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSL0
      Conserved Domains (1) summary
      pfam14360
      Location:259 → 332
      PAP2_C; PAP2 superfamily C-terminal

    3. NM_001330978.3 → NP_001317880.1  Sphingomyelin synthase-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSK5
      Conserved Domains (1) summary
      pfam14360
      Location:194 → 267
      PAP2_C; PAP2 superfamily C-terminal

    4. NM_001330979.3 → NP_001317881.1  Sphingomyelin synthase-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSJ8
      Conserved Domains (1) summary
      pfam14360
      Location:208 → 281
      PAP2_C; PAP2 superfamily C-terminal

    5. NM_001330980.3 → NP_001317882.1  Sphingomyelin synthase-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSJ9
      Conserved Domains (1) summary
      pfam14360
      Location:2 → 75
      PAP2_C; PAP2 superfamily C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q965Q4.1

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