pup-2 PAP-associated domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pup-2
Official Full Name: PAP-associated domain-containing protein
Primary source: WormBase:WBGene00019628
Locus tag: CELE_K10D2.2
See related: AllianceGenome:WB:WBGene00019628
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA uridylyltransferase activity. Involved in pre-miRNA processing. Is expressed in germ line. Human ortholog(s) of this gene implicated in liver benign neoplasm. Orthologous to human TUT4 (terminal uridylyl transferase 4) and TUT7 (terminal uridylyl transferase 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pup-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (5185920..5188587)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans
Title: LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS3-7 (e-PCR)
- UniSTS:242082

K10D2.2 (e-PCR)
- UniSTS:311538

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA uridylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA uridylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA 3' uridylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in pre-miRNA processing	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PAP-associated domain-containing protein

NP_498100.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5185920..5188587

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065699.6 → NP_498100.1 PAP-associated domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498100.1

Status: REVIEWED

UniProtKB/TrEMBL

Q09408

Conserved Domains (2) summary

cd05402
Location:163 → 264

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

COG5260
Location:169 → 414

TRF4; DNA polymerase sigma [Replication, recombination and repair]