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    bus-8B Alpha-1,3/1,6-mannosyltransferase ALG2 [ Caenorhabditis elegans ]

    Gene ID: 180821, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bus-8B
    Official Full Name
    Alpha-1,3/1,6-mannosyltransferase ALG2
    Primary source
    WormBase:WBGene00044623
    Locus tag
    CELE_T23F2.1
    See related
    AllianceGenome:WB:WBGene00044623
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable alpha-1,3-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in membrane. Predicted to be active in endomembrane system. Is expressed in seam cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bus-8B in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (5493390..5496050)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ovule protein Neighboring gene ncRNA Neighboring gene GRIP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The FDA-approved drugs ticlopidine, sertaconazole, and dexlansoprazole can cause morphological changes in C. elegans. Galford KF, et al. Chemosphere, 2020 Dec. PMID 32731027, Free PMC Article
    2. An enhanced C. elegans based platform for toxicity assessment. Xiong H, et al. Sci Rep, 2017 Aug 29. PMID 28852193, Free PMC Article
    3. Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity. McCormick AV, et al. Biol Psychiatry, 2013 Mar 1. PMID 23140663, Free PMC Article
    4. The C. elegans glycosyltransferase BUS-8 has two distinct and essential roles in epidermal morphogenesis. Partridge FA, et al. Dev Biol, 2008 May 15. PMID 18395708
    5. A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing. Pandarakalam GC, et al. Int J Parasitol Drugs Drug Resist, 2019 Aug. PMID 31015150, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-1,3-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Alpha-1,3/1,6-mannosyltransferase ALG2
    NP_001408285.1
    • Confirmed by transcript evidence
    NP_508932.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5493390..5496050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001421340.1 → NP_001408285.1  Alpha-1,3/1,6-mannosyltransferase ALG2 [Caenorhabditis elegans]

      Status: REVIEWED

    2. NM_076531.8 → NP_508932.1  Alpha-1,3/1,6-mannosyltransferase ALG2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508932.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECB6
      Conserved Domains (2) summary
      cd03805
      Location:1 → 383
      GT1_ALG2_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2) ...
      COG0438
      Location:1 → 392
      RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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