rsd-3 ENTH domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rsd-3
Official Full Name: ENTH domain-containing protein
Primary source: WormBase:WBGene00004682
Locus tag: CELE_C34E11.1
See related: AllianceGenome:WB:WBGene00004682
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable clathrin binding activity and phospholipid binding activity. Predicted to be involved in endocytosis. Predicted to be located in cytosol. Predicted to be part of clathrin vesicle coat. Predicted to be active in endosome and plasma membrane. Is expressed in several structures, including coelomocyte; excretory canal; hypodermis; intestine; and pharynx. Orthologous to human CLINT1 (clathrin interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rsd-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (11798505..11803656)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RSD-3 is required for importing silencing RNA into cells rather than exporting from cells.
Title: Endomembrane-associated RSD-3 is important for RNAi induced by extracellular silencing RNA in both somatic and germ cells of Caenorhabditis elegans.
epsin plays a specific, evolutionarily conserved role to promote Notch signaling during animal development
Title: Epsin potentiates Notch pathway activity in Drosophila and C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C34E11.1 (e-PCR)
- UniSTS:306763

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of clathrin vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ENTH domain-containing protein

NP_509973.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11798505..11803656

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077572.8 → NP_509973.1 ENTH domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509973.1

Status: REVIEWED

UniProtKB/TrEMBL

Q18453

Conserved Domains (1) summary

cd16989
Location:42 → 173

ENTH_EpsinR; Epsin N-Terminal Homology (ENTH) domain of Epsin-related protein