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    rab-37 RAB family [ Caenorhabditis elegans ]

    Gene ID: 180696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rab-37
    Official Full Name
    RAB family
    Primary source
    WormBase:WBGene00004285
    Locus tag
    CELE_W01H2.3
    See related
    AllianceGenome:WB:WBGene00004285
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in regulation of exocytosis. Predicted to be active in Golgi apparatus and endosome. Is expressed in head neurons and tail neurons. Orthologous to human RAB26 (RAB26, member RAS oncogene family) and RAB37 (RAB37, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rab-37 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (4227810..4235846, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complementary RNA amplification methods enhance microarray identification of transcripts expressed in the C. elegans nervous system. Watson JD, et al. BMC Genomics, 2008 Feb 19. PMID 18284693, Free PMC Article
    2. Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans. Mahoney TR, et al. Mol Biol Cell, 2006 Jun. PMID 16571673, Free PMC Article
    3. Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density. Gracheva EO, et al. Neurosci Lett, 2008 Oct 24. PMID 18721860, Free PMC Article
    4. Regulation of membrane trafficking by a novel Cdc42-related protein in Caenorhabditis elegans epithelial cells. Jenna S, et al. Mol Biol Cell, 2005 Apr. PMID 15659649, Free PMC Article
    5. GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48. Caruso ME, et al. Mol Cell Biol, 2008 Jul. PMID 18458060, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RAB family
    NP_001041294.1
    • Product from WormBase gene class rab;
      Confirmed by transcript evidence
    NP_001300382.1
    • Product from WormBase gene class rab;
      Confirmed by transcript evidence
    NP_001359998.1
    • Product from WormBase gene class rab;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4227810..4235846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373276.3 → NP_001359998.1  RAB family [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4SEK4, I7F4A3
      Conserved Domains (1) summary
      smart00175
      Location:1 → 160
      RAB; Rab subfamily of small GTPases

    2. NM_001313453.4 → NP_001300382.1  RAB family [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASU7, I7F4A3
      Conserved Domains (2) summary
      smart00175
      Location:18 → 180
      RAB; Rab subfamily of small GTPases
      cd00154
      Location:22 → 175
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

    3. NM_001047829.5 → NP_001041294.1  RAB family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041294.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFA6, I7F4A3
      Conserved Domains (2) summary
      smart00175
      Location:30 → 192
      RAB; Rab subfamily of small GTPases
      cd00154
      Location:30 → 187
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    Nucleotide Protein
    Heading Accession and Version

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