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    hlh-11 Helix-loop-helix protein 11 [ Caenorhabditis elegans ]

    Gene ID: 176360, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hlh-11
    Official Full Name
    Helix-loop-helix protein 11
    Primary source
    WormBase:WBGene00001955
    Locus tag
    CELE_F58A4.7
    See related
    AllianceGenome:WB:WBGene00001955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including excretory cell; intestine; male-specific anatomical entity; non-striated muscle; and somatic nervous system. Orthologous to human TFAP4 (transcription factor AP-4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hlh-11 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (9622147..9626528)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Histone H3-like centromeric protein hcp-3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tubulin gamma chain Neighboring gene putative DNA-directed RNA polymerases I and III subunit RPAC2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HLH-11 modulates lipid metabolism in response to nutrient availability. Li Y, et al. Nat Commun, 2020 Nov 24. PMID 33235199, Free PMC Article
    2. Identification and characterization of a putative basic helix-loop-helix (bHLH) transcription factor interacting with calcineurin in C. elegans. Lee SU, et al. Mol Cells, 2009 Nov 30. PMID 19855932
    3. Betulinic acid counteracts the lipid accumulation in Caenorhabditis elegans by modulation of nhr-49 expression. Savova MS, et al. Biomed Pharmacother, 2022 Dec. PMID 36242845
    4. A feedback loop governs the relationship between lipid metabolism and longevity. Littlejohn NK, et al. Elife, 2020 Oct 20. PMID 33078707, Free PMC Article
    5. Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response. Watson E, et al. Cell, 2013 Mar 28. PMID 23540702, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HLH-11 modulates lipid metabolism in response to nutrient availability.
      Title: HLH-11 modulates lipid metabolism in response to nutrient availability.
    2. hlh-11 may function to regulate serotonin-mediated egg laying at the downstream of tax-6.
      Title: Identification and characterization of a putative basic helix-loop-helix (bHLH) transcription factor interacting with calcineurin in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Helix-loop-helix protein 11
    NP_001367058.1
    • Confirmed by transcript evidence
    NP_499129.2
    • Confirmed by transcript evidence
    NP_499130.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9622147..9626528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066728.8 → NP_499129.2  Helix-loop-helix protein 11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499129.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34474, Q7JMU4, Q7YXC9, Q86DA4, Q9U3E1
      Conserved Domains (1) summary
      pfam00010
      Location:113 → 163
      HLH; Helix-loop-helix DNA-binding domain

    2. NM_001379865.2 → NP_001367058.1  Helix-loop-helix protein 11 [Caenorhabditis elegans]

      Status: REVIEWED

    3. NM_066729.10 → NP_499130.2  Helix-loop-helix protein 11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499130.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34474
      Conserved Domains (1) summary
      pfam00010
      Location:111 → 161
      HLH; Helix-loop-helix DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34474.3

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