exo-1 Exonuclease 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: exo-1
Official Full Name: Exonuclease 1
Primary source: WormBase:WBGene00009731
Locus tag: CELE_F45G2.3
See related: AllianceGenome:WB:WBGene00009731
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 5'-3' DNA exonuclease activity and 5'-flap endonuclease activity. Predicted to be involved in DNA recombination and mismatch repair. Predicted to be active in nucleus. Orthologous to human EXO1 (exonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See exo-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (13423514..13426204)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans.
Title: Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F45G2.3 (e-PCR)
- UniSTS:307656

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 5'-3' DNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-3' DNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 5'-flap endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Exonuclease 1

NP_499770.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

13423514..13426204

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067369.5 → NP_499770.1 Exonuclease 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499770.1

Status: REVIEWED

UniProtKB/TrEMBL

O62245

Conserved Domains (2) summary

cd09908
Location:219 → 298

H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease

cd09857
Location:1 → 205

PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs