ani-1 Anillin-like protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ani-1
Official Full Name: Anillin-like protein 1
Primary source: WormBase:WBGene00013038
Locus tag: CELE_Y49E10.19
See related: AllianceGenome:WB:WBGene00013038
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables actin filament binding activity; microtubule binding activity; and small GTPase binding activity. Involved in several processes, including cytoskeleton organization; first cell cycle pseudocleavage; and nematode male tail tip morphogenesis. Located in several cellular components, including cleavage furrow; growth cone; and midbody. Is expressed in several structures, including QL; QR; germ line; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin, actin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ani-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (12446353..12453202, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIM-4 is an extracellular factor that regulates ANI-1 for germ cell membrane stabilization and contractile ring formation in Caenorhabditis elegans germline cells.
Title: An extracellular matrix protein promotes anillin-dependent processes in the Caenorhabditis elegans germline.
During the first cytokinesis of the Caenorhabditis elegans embryo, the amount of ring components (myosin, anillin) and the constriction rate increase with parallel exponential kinetics.
Title: A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in Caenorhabditis elegans.
ANI-1 and ANI-2 contribute to embryonic viability by performing distinct functions in the early embryo and gonad, respectively [ANI-1 & ANI-2]
Title: Distinct roles for two C. elegans anillins in the gonad and early embryo.
active form of RhoG/MIG-2 directly binds to Anillin and recruits it to the leading edge of Q neuroblasts
Title: Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton.
Caenorhabditis elegans anillin (ani-1) regulates neuroblast cytokinesis and epidermal morphogenesis during embryonic development.
Title: Caenorhabditis elegans anillin (ani-1) regulates neuroblast cytokinesis and epidermal morphogenesis during embryonic development.
Anillin-1 promotes astral microtubule-directed cortical myosin polarization
Title: Anillin promotes astral microtubule-directed cortical myosin polarization.
Anillin is dispensable for contractile ring assembly, initiation, and closure but is required for the meiotic contractile ring to transform from a disc into a tube.
Title: Actomyosin tube formation in polar body cytokinesis requires Anillin in C. elegans.
Asymmetric ingression requires Anillin and the septins, which promote the coalescence of components on one side of the contractile ring, but is insensitive to a 10-fold reduction in myosin II levels.
Title: Anillin and the septins promote asymmetric ingression of the cytokinetic furrow.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y49E10.19 (e-PCR)
- UniSTS:317321

Y49E10.20 (e-PCR)
- UniSTS:317322

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in actomyosin contractile ring assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in collagen and cuticulin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in first cell cycle pseudocleavage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polar body extrusion after meiotic divisions	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septin ring organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in septin ring organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actomyosin contractile ring	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Anillin-like protein 1

NP_499624.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

12446353..12453202 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067223.9 → NP_499624.2 Anillin-like protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499624.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XTT4

Conserved Domains (4) summary

cd01263
Location:1029 → 1150

PH_anillin; Anillin Pleckstrin homology (PH) domain

pfam00169
Location:1030 → 1147

PH; PH domain

pfam08174
Location:840 → 995

Anillin; Cell division protein anillin

pfam15547
Location:420 → 517

DUF4654; Domain of unknown function (DUF4654)