cdc-25.3 M-phase inducer phosphatase cdc-25.3 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: cdc-25.3
Official Full Name: M-phase inducer phosphatase cdc-25.3
Primary source: WormBase:WBGene00000388
Locus tag: CELE_ZK637.11
See related: AllianceGenome:WB:WBGene00000388
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; and positive regulation of G2/MI transition of meiotic cell cycle. Located in nucleus. Is expressed in ABa; ABp; and germ line. Human ortholog(s) of this gene implicated in autosomal recessive polycystic kidney disease; cervical cancer; endometrial cancer; prostate cancer; and urinary bladder cancer. Orthologous to human CDC25A (cell division cycle 25A); CDC25B (cell division cycle 25B); and CDC25C (cell division cycle 25C). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See cdc-25.3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (8916351..8917929, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

elevation of germline apoptosis in cdc-25.3 mutants is induced by accumulation of DSBs
Title: Depletion of cdc-25.3, a Caenorhabditis elegans orthologue of cdc25, increases physiological germline apoptosis.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

ZK637.11 (e-PCR)
- UniSTS:313638

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell cycle G2/M phase transition	IEA Inferred from Electronic Annotation more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: M-phase inducer phosphatase cdc-25.3

NP_498972.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8916351..8917929 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066571.7 → NP_498972.1 M-phase inducer phosphatase cdc-25.3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498972.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P30634

Conserved Domains (1) summary

cd01530
Location:116 → 235

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...