U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    odr-8 Ufm1-specific protease [ Caenorhabditis elegans ]

    Gene ID: 177417, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    odr-8
    Official Full Name
    Ufm1-specific protease
    Primary source
    WormBase:WBGene00018160
    Locus tag
    CELE_F38A5.1
    See related
    AllianceGenome:WB:WBGene00018160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables deUFMylase activity. Involved in several processes, including positive regulation of chemotaxis; protein localization to non-motile cilium; and response to ethanol. Part of protein-containing complex. Is expressed in hypodermis; intestine; and nervous system. Used to study early infantile epileptic encephalopathy. Human ortholog(s) of this gene implicated in Beukes hip dysplasia and developmental and epileptic encephalopathy 106. Orthologous to human UFSP2 (UFM1 specific peptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See odr-8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (6579836..6582704, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Methyltransf_21 domain-containing protein;Secreted protein Neighboring gene TraB domain-containing protein Neighboring gene DnaJ homolog subfamily C member 2 Neighboring gene Galectin

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structural basis for Ufm1 recognition by UfSP. Kim KH, et al. FEBS Lett, 2018 Jan. PMID 29251776
    2. The MPN domain of Caenorhabditis elegans UfSP modulates both substrate recognition and deufmylation activity. Ha BH, et al. Biochem Biophys Res Commun, 2016 Aug 5. PMID 27240952
    3. The ubiquitin-fold modifier 1 (Ufm1) cascade of Caenorhabditis elegans. Hertel P, et al. J Biol Chem, 2013 Apr 12. PMID 23449979, Free PMC Article
    4. Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein. Dwyer ND, et al. Cell, 1998 May 1. PMID 9590179
    5. Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy. Colin E, et al. Am J Hum Genet, 2016 Sep 1. PMID 27545681, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deUFMylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deUFMylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to non-motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ethanol IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ufm1-specific protease
    NP_001023188.1
    • Confirmed by transcript evidence
    NP_001023189.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6579836..6582704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028017.4 → NP_001023188.1  Ufm1-specific protease [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023188.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86MF8, Q94218
      Conserved Domains (1) summary
      pfam07910
      Location:395 → 580
      Peptidase_C78; Peptidase family C78

    2. NM_001028018.2 → NP_001023189.1  Ufm1-specific protease [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023189.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94218
      Conserved Domains (1) summary
      pfam07910
      Location:381 → 566
      Peptidase_C78; Peptidase family C78
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94218.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools