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    csn-6 COP9 signalosome complex subunit 6 [ Caenorhabditis elegans ]

    Gene ID: 178289, updated on 9-Dec-2024

    Summary

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    Official Symbol
    csn-6
    Official Full Name
    COP9 signalosome complex subunit 6
    Primary source
    WormBase:WBGene00000818
    Locus tag
    CELE_Y67H2A.6
    See related
    AllianceGenome:WB:WBGene00000818
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metallopeptidase activity. Predicted to be involved in oogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of COP9 signalosome. Orthologous to human COPS6 (COP9 signalosome subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See csn-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (13300824..13303711)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Calcium uptake protein 1 homolog, mitochondrial Neighboring gene KASH (Klarsicht/ANC-1/Syne Homology) Domain Protein Neighboring gene Peptidase M3A/M3B catalytic domain-containing protein Neighboring gene Omega-3 fatty acid desaturase fat-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CSN-5, a component of the COP9 signalosome complex, regulates the levels of UNC-96 and UNC-98, two components of M-lines in Caenorhabditis elegans muscle. Miller RK, et al. Mol Biol Cell, 2009 Aug. PMID 19535455, Free PMC Article
    2. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Pintard L, et al. Curr Biol, 2003 May 27. PMID 12781129
    3. COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells. Osterli E, et al. Genetics, 2024 May 7. PMID 38427913,
    4. CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo. Luke-Glaser S, et al. Mol Cell Biol, 2007 Jun. PMID 17403899, Free PMC Article
    5. Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Koyuncu S, et al. Nature, 2021 Aug. PMID 34321666, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 6
    NP_001255725.1
    • Confirmed by transcript evidence
    NP_001255726.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13300824..13303711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268797.3 → NP_001255726.1  COP9 signalosome complex subunit 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255726.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95PZ0
      Conserved Domains (1) summary
      cl13996
      Location:13 → 269
      MPN; Mpr1p, Pad1p N-terminal (MPN) domains

    2. NM_001268796.5 → NP_001255725.1  COP9 signalosome complex subunit 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255725.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5VUK2
      Conserved Domains (1) summary
      cl13996
      Location:13 → 269
      MPN; Mpr1p, Pad1p N-terminal (MPN) domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95PZ0.1

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