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    copa-1 Coatomer subunit alpha [ Caenorhabditis elegans ]

    Gene ID: 171860, updated on 9-Dec-2024

    Summary

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    Official Symbol
    copa-1
    Official Full Name
    Coatomer subunit alpha
    Primary source
    WormBase:WBGene00022119
    Locus tag
    CELE_Y71F9AL.17
    See related
    AllianceGenome:WB:WBGene00022119
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in Golgi vesicle transport and intracellular protein transport. Predicted to be located in COPI-coated vesicle membrane and Golgi membrane. Predicted to be part of COPI vesicle coat. Is expressed in several structures, including body wall musculature; intestine; pharynx; reproductive system; and seam cell. Human ortholog(s) of this gene implicated in autoimmune interstitial lung, joint, and kidney disease. Orthologous to human COPA (COPI coat complex subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See copa-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (2895329..2900860, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Actin-related protein 3 Neighboring gene Clathrin light chain Neighboring gene Protein PBN1 Neighboring gene maleylacetoacetate isomerase Neighboring gene Tyrosine-protein phosphatase Neighboring gene Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. copa-1 mutants experience heightened endoplasmic reticulum stress sensitivity in a C. elegans COPA Syndrome model. Larkin KA, et al. MicroPubl Biol, 2023. PMID 36748043, Free PMC Article
    2. Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans. Mosquera JV, et al. PLoS Genet, 2021 Jun. PMID 34133414, Free PMC Article
    3. Genome-Wide Mutational Signature of the Chemotherapeutic Agent Mitomycin C in Caenorhabditis elegans. Tam AS, et al. G3 (Bethesda), 2015 Nov 12. PMID 26564951, Free PMC Article
    4. Semi-supervised analysis of gene expression profiles for lineage-specific development in the Caenorhabditis elegans embryo. Qi Y, et al. Bioinformatics, 2006 Jul 15. PMID 16873502
    5. The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling. Rüegger S, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25753661, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans.
      Title: Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in COPI-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Coatomer subunit alpha
    NP_491069.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2895329..2900860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058668.6 → NP_491069.1  Coatomer subunit alpha [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491069.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4H7
      Conserved Domains (5) summary
      COG2319
      Location:14 → 503
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:7 → 317
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam04053
      Location:341 → 770
      Coatomer_WDAD; Coatomer WD associated region
      pfam06957
      Location:820 → 1227
      COPI_C; Coatomer (COPI) alpha subunit C-terminus
      sd00039
      Location:17 → 51
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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