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    txl-1 Thioredoxin-like protein [ Caenorhabditis elegans ]

    Gene ID: 171897, updated on 9-Dec-2024

    Summary

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    Official Symbol
    txl-1
    Official Full Name
    Thioredoxin-like protein
    Primary source
    WormBase:WBGene00021826
    Locus tag
    CELE_Y54E10A.3
    See related
    AllianceGenome:WB:WBGene00021826
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-disulfide reductase activity. Predicted to be active in cytosol. Orthologous to human TXNL1 (thioredoxin like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See txl-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (3229431..3233286)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene rhomboid protease Neighboring gene CDT1 Geminin-binding domain-containing protein Neighboring gene Conserved oligomeric Golgi complex subunit 1 Neighboring gene ncRNA Neighboring gene Male abnormal protein mab-31

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Redox System in C. elegans, a Phylogenetic Approach. Johnston AD, et al. J Toxicol, 2012. PMID 22899914, Free PMC Article
    2. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Thioredoxin-like protein
    NP_491127.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3229431..3233286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058726.8 → NP_491127.1  Thioredoxin-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491127.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EES9
      Conserved Domains (2) summary
      cd02947
      Location:10 → 103
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      pfam06201
      Location:121 → 262
      PITH; PITH domain
    Nucleotide Protein
    Heading Accession and Version

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